The physiological disposition and metabolic fate of cortisone in man.

The metabolism of corticosterone in man.

Corticosterone was the first biologically active hormone to be isolated from adrenal gland extracts (1, 2). Although contributing little to the body pool of adrenocortical steroids in man, it is one of the major adrenocortical secretory products in some animals, e.g., rodents (3). In man the major glucocorticosteroid is cortisol and the major mineralocorticosteroid is probably aldosterone; neve...

Studies on human growth hormone. II. The physiological disposition and metabolic fate of human growth hormone in man.

Fate and Unity of Existence in Comparative Philosophy of Molana and Sultan Valad Conduct in Masnavi Molavi and Sultanvalad Masnavies

This study, based on library studies and written in a descriptive-analytical manner,The researcher examine comparatively the topics of "fate" and "unity of existence" in Masnavi Molavi and Masnavies of Sulan valad (Ebtedaname, Robabname and Entehaname). The results show that Fate is one of the most basic teachings of Maulana and Sultan valad. From their point of view, unless the mystic reach th...

Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery.

The dopamine agonist rotigotine was developed for the treatment of Parkinson's disease and restless legs syndrome. Disposition, metabolism, elimination, and absolute bioavailability of rotigotine were determined in six healthy male subjects by using two different forms of administration in a randomized sequence with a crossover design. Treatment A (continuous infusion) consisted of a single rad...

The fate of melatonin in animals.

,Melatonin (N-acetyl-5-methoxytryptamine), the most potent melanocyte-contracting substance known, has been demonstrated in bovine pineal glands and peripheral nerve of man, monkey, and cattle (1,2). Its formation from seratonin, by.N-acotylation (3) and subsequent 0-methylation (4), has been indicated. In a preliminary communication, we provided evidence for 6-hydroxylation as the major metabo...